If you’re not familiar with the concept of memetics, I’d recommend reading the wikipedia article before this post.
There are two broad ways for memes to transmit: horizontal/viral and vertical/mitochondrial. Horizontal/viral is peer-to-peer (extreme example: antinatalism. Almost no one gets their antinatalism from their parents), vertical/mitochondrial is from parent to child, or previous generation to next generation (extreme example: Haredi Judaism. Almost every Haredi Jew is the children of Haredi Jews). Most memes have elements of both; for instance the vast majority of Muslims are Muslim because their parents were, but Islam is also a proselytizing religion. The balance between these two modes of transmission has important implications for the content of a meme.
Over time, mostly-mitochondrial memes tend to evolve to become symbiotic with the people they inhabit, like mitochondria, and for the same reason: they depend on the reproduction of those people/communities to spread. That means they tend to produce societies that can reproduce themselves, feed themselves, and are strong enough to defend themselves from (or conquer) other, competing societies with distinct memeplexes. In other words, functional societies. Mitochondrial memeplexes that produce highly dysfunctional people or societies get selected out and go extinct (see: the Shakers, an antinatalist Christian sect in the US).

Much like actual viruses, viral memeplexes have no need to help their hosts, because they spread among unrelated people rather than parent to child. Principally viral memes will happily stop you from reproducing (trans ideology), convince you to go to war with far stronger opponents (Nazism), or starve you to death (Xhosa cattle killing). Smallpox doesn’t care about you and neither does LGBT ideology; both are just using you to spread to their next host. Principally viral memeplexes don’t optimize for functional people or societies, they optimize for virulence/transmissibility. Because there are tradeoffs between virulence and functionality, where more virulence means less functionality or vice versa, extremely viral memes evolve towards creating ever more dysfunctional people/societies.

Just as viruses can become more virulent by simply increasing viral multiplication (Delta variant of COVID), causing coughing or sneezing (most respiratory viruses), creating diarrhea (cholera), or altering behavior to favor viral spread (the flu), there are many ways for memes to become more virulent. The most obvious is to sound good to people. This might sound OK, but just as food optimized for tasting good (highly processed junk food) or drugs optimized for feeling good (fentanyl) are not good for you, ideas optimized for sounding good are not likely to be good for you. Hijacking and appealing to basic human urges like tribalism (Nazism) or envy (communism) will sound great to a lot of people, but are ultimately disastrous. But there are other ways to be virulent as well: intolerance towards competing memeplexes (eg early Christianity vs paganism, or Wokeness vs Classical Liberalism) to crush competitors rather than convince them, or optimizing for taking over institutions that have the “cultural high ground” (education, academia, journalism, entertainment, social media) can both increase virulence without making the memeplex more convincing. Sometimes, multiple elements of a memeplex will work together to make the whole thing more virulent without becoming more convincing; consider the Progressive mantra to “Trust the Experts'' or “Trust the Science.” By themselves, these are not particularly virulent memes; “Trust your Priest,” or “Have Faith” have historically been much more convincing. But when combined with the overwhelming dominance of academia and the credentialing apparatus by the Left, these memes make the whole leftist memeplex more virulent.

The memetic environment of the preindustrial past generally favored mitochondrial transmission over viral transmission because communication between peers was slow. It took centuries for Christianity to take over the Roman Empire, and a big chunk of that was through sheer natural increase (mitochondrial). This meant that memeplexes had to be at least somewhat mitochondrial to last long, because they simply couldn’t transmit quickly enough to survive if they destroyed their hosts, no matter how virulent they were. Technological advances like the printing press, telegraph, radio, universal literacy, television, the internet, and social media have massively sped up communication and interconnection, favoring viral memeplexes. Thanks to social media, anyone in the world who is literate in English and has an internet connection can now transmit memes to billions of other people. It’s the memetic equivalent of a 19th century urban slum with no sewers or sanitation.

This explains the link between social media and the Great Awokening: the memetic environment created by social media massively empowered viral memes, leading to “wokeness,” the most recent incarnation of progressivism and an incredibly virulent and dysfunctional memeplex that has taken over the world. The other checks on viral memes getting too dysfunctional, intergroup conflict and Malthusian constraints, are also effectively gone due to nuclear weapons and the industrial revolution. This is why Christian heresies very similar to modern Progressivism (Shakers, Cathars, Bogomils, Fifth Monarchists, Diggers) are common throughout European history, but nothing like Progressivism ever really took off until the environment became much more favorable to viral memes.
Putting it all together, a memetic environment with more or less free competition which strongly favors viral over mitochondrial transmission and in which Malthusian and conflict constraints are removed (like that of the United States from the destruction of speech codes in the ~1960s to the rise of political correctness in the ~1990s) will lead to the development of an extremely virulent viral memeplex that renders its hosts utterly dysfunctional and eventually destroys them as it optimizes for ever more virulence at the expense of its hosts’ functionality. Today, this is the memeplex known as Progressivism or Wokeness, an ideology that valorizes and promotes every form of human dysfunction, from criminality to stupidity to mental illness to sterility to obesity. For some examples of dysfunction on both an individual and societal level, see what trans ideology does to people, or a graph of global TFRs, or what’s happened to San Francisco over the past couple decades. The collapse of civilization is the inevitable result.

Fantastic read, my friend.
If you keep the comparison to regular viruses, for a moment, would we not see a adaptation to these new forms of communication, through modification of other memes (hygene) and genetic selection towards living in this environment, by selecting against high openness and intelligence, and for memetic stability?
Historically, the great plagues always occured in times after parts of the world had been connected, that were not as connected before, and after population density increased a lot.
You got the black death after the mongols connected Europe and Asia properly with certain modifications of the existing silk road, smallpox after Europeans discovered America and so on.
But all these diseases were a one time thing. You do not have constant black deaths in Europe now, because we adapted to this crisis (mostly memetically, and with better tech). Would you not expect the same after leftism is finally dead? That we would then adapt new behaviours do deal with memetic viruses, digital hygene, so to speak? Do we really need the more radical solutions (going full uncle ted etc) in that light?
I don't think a new religion is coming, and a revival of old religion is much more likely. (Russia has had success with this.) Also, with the non-heterosexual identity, we don't see a big move towards homosexuality. I suspect what we're seeing instead is a lot of bisexual women (who only date men).